Familial /sporadic gastrointestinal stromal tumors (GISTs)

Synchronous sporadic gastrointestinal stromal tumors (GISTs) of the colon.

Gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors of the gastrointestinal tract originating from the cell of Cajal [1]. Up to 75% of cases are driven by constitutional activation of the proto-oncogene cKIT; 10% by a mutation of the gene encoding for the platelet-derived growth factor receptor (PDGFRA); 12% are wild-type and their pathogenesis has been related to mutations of t...

Gastrointestinal stromal tumors (GISTs) and second malignancies

Several evidences showed that patients with gastrointestinal stromal tumors (GISTs) develop additional malignancies. However, thorough incidence of second tumors remains uncertain as the possibility of a common molecular pathogenesis.A retrospective series of 128 patients with histologically proven GIST treated at our institution was evaluated. Molecular analysis of KIT and PDGFR-α genes was pe...

Surgical Treatment of Gastrointestinal Stromal Tumors (GISTs)

Gastrointestinal stromal tumors (GISTs) of the colon.

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal (GI) tract. Although they may arise anywhere of GI tract, colonic presentation is infrequent. We report 2 new cases of colonic GISTs localized at descending and sigmoid colon. Endoscopic biopsies were diagnostic for GISTs and no distant metastasis were observed. Both cases underwent resective ...

Gastrointestinal stromal tumors (GISTs) of the stomach: a multicenter, retrospective study of curatively resected gastric GISTs

PURPOSE The standard treatment for primary localized gastric gastrointestinal stromal tumor (GIST) is surgical resection. The clinical behavior of gastric GIST after surgical resection is extremely variable. We conducted a multicenter, retrospective study of gastric GISTs patients who underwent curative surgical resection to evaluate clinical features and the prognosis of surgically treated gas...